The time required for the maximal enlargement per 100 g. bodyweight waa 12 days. Exocrine glands use ducts to excrete substances. About the same time, Bielschowsky re- ported the presence of both benign and ma- lignant tumors in the thyroid glands ofrats fed 2-acetylaminofluorene and ally1 thiourea. Share This Article: Copy. n. A white crystalline compound, C4H4N2OS, that interferes with the synthesis of thyroxine, used to reduce the action of the thyroid gland, especially in... Thiouracil - definition of thiouracil by The Free Dictionary. Thyroid hormone production is also seasonal in nature with concentrations being highest during the winter months and lowest during the long days of summer (Karsch et al., 1995; Souza et al., 2002). To incorporate these facts into the current concept of thyrotropic exophthalmos one must conclude that the moderately overactive thyroid gland is less capable of inactivating thyrotropin than is the gland completely blocked but hyper- trophic and hyperplastic under the influence of propyi thiouracil. By JEAN E. SELLE, RAYMOND M. SELLE. Thiouracil is a sulfur-containing uracil.An established antithyroid drug and highly selective inhibitor of nitric oxide synthase (NOS), thiouracil also covalently binds to dopaquinone, produced by tyrosinase catalyzed oxidation of tyrosine, thereby selectively accumulating in de novo-synthesized melanin in overactive melanin-producing cells and providing a means to localize melanoma cells. The term goiter is used to describe any enlargement of the thyroid gland, which can be caused by iodine deficiency or a thyroid disorder. Effects of intraperitoneal injections of thyroid gland suspensions and oral methyl thiouracil administration in rats. Search for other works by this author on: Oxford Academic. [Pregnancy and thiouracil adenoma of the thyroid gland]. extent the thyroid. LAQ1JEUR—Hyperplasia of Thyroid Glands and Thiouracil 9249 The nuclei of the epithelial cells were more com pact and smaller than in the remaining @g1and. These hormones are necessary for all the cells in your body to work normally. thiouracil synonyms, thiouracil pronunciation, thiouracil translation, English dictionary definition of thiouracil. Authors: Lees, J; Alexander, W D; Marchant, B Publication Date: Sun Jul 01 00:00:00 EDT 1973 Research Org. If a glass be present, it must have been fluid at the temperature of the run, for the glass conforms to the bottom of the chamber and has a flat surface which is substantially horizontal. OSTI.GOV Technical Report: The Effect of Thiouracil on the Uptake of Radioactive Iodine by the Thyroid Gland of Summer Frogs (Rana pipiens) The Effect of Thiouracil on the Uptake of Radioactive Iodine by the Thyroid Gland of Summer Frogs (Rana pipiens) Full Record; Other Related Research; Authors: Matthews, S.A. The effect of thyroid and thiouracil on the natural resistance of mice to infection with Hymenolepis J Parasitol. The isthmus usually overlies the region from the 2nd to 4th tracheal cartilage. The changes in weight and morphology of the thyroid gland and hypophysis following chronic administration of thiouracil in the diet have been described. It was first pointed out by the Mackenzies and. Thyroid gland and thyroprotein or thiouracil The administration of certain sulfonamides or thiourea results in an enlarged, hyperemic, and hyperplastic thyroid gland coincident with the state of hypothyroidism. 6.33): i. Iodide trapping that is the uptake of iodide by the follicular cells from the plasma against the electrochemical gradient. Addition of 0.1 per cent, thiouracil or thiourea to the diet of white Plymouth Bock chicks up to 14 days old, caused increased thyroid weight, the degree of enlargement being greater in females, than in males. 1955;144(3):288-94. [Article in German] GITSCH E, REITINGER J. HOPSU VK, KARINKANTA H. Annales Medicinae Experimentalis et Biologiae Fenniae, 01 Jan 1962, 40: 1-7 PMID: 14448829 . The selective uptake of 14C- and ‘251-thiouracil in mela- nomas depends on their acceptance as false melanin precur- sors, making them specific markers for growing melanin. Get this from a library! ADMINISTRATION of thiouracil to rhesus monkeys (Macaca mulatta) causes hyperplasia and colloid depletion in monkeys as it does in other animals and in man. 6.32): The steps in the biosynthesis of the hormone are (Fig. The thyroid gland is an endocrine gland in your neck. Structural changes in the thyroid gland of buffalo following administration of thiouracil. Google Scholar. It was the object of this investigation to determine whether the endocrine function of the human thyroid gland could be inhibited by these compounds and to obtain information concerning their dosage and toxicity in individuals with normal thyroid glands and in cases of hyperthyroidism. Save to my folders. Thyroid gland The thyroid gland is one of the largest endocrine glands. The hormone TSH secreted by the anterior pituitary gland affects this step. [Samuel Arthur Matthews; … 1. gland. By feeding dl-thyroxine with thiouracil, the thyroid weight was decreased. Title: The Effects of Thiouracil on the Thyroid Gland of Triturus Viridescens: Authors: Marshall, Jr., Jerome Benjamin: Department: Biology: Class Year: thiouracil: A white crystalline compound, C 4 H 4 N 2 OS, that interferes with the synthesis of thyroxine, used to reduce the action of the thyroid gland, especially in the treatment of hyperthyroidism. The thyroid gland plays an important physiological role in the body. References. There was evidence of involution of the thyroid gland in male rats which had received the diet for 10 months. CARPEN E, CARPEN I, TEIR H. Acta Endocrinol (Copenh), 22(4):395-406, 01 Aug 1956 Cited by: 0 articles | PMID: 13354230 Define thiouracil. Answer: (c) 9. 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